Question 1

What is AOD-9604?

Accepted Answer

AOD-9604 is a synthetic sixteen-amino-acid peptide corresponding to residues 176-191 of a larger endogenous polypeptide sequence, with a tyrosine residue added at the N-terminus. Because it reproduces only that terminal region, it lacks the receptor-binding domains of the parent molecule, which is why it is studied as a discrete sequence rather than as a stand-in for it. Published work characterizes it in adipocyte cultures and rodent models examining lipolytic signaling pathways. Prime Science Supply supplies AOD-9604 as a Research Use Only material. It is not an approved drug and is not intended for human or veterinary use.

Question 2

What does purity of at least 98% by HPLC-UV mean?

Accepted Answer

High-performance liquid chromatography with ultraviolet detection separates the components of a sample and measures the area under each resulting peak. A result of at least 98% purity means the peak corresponding to the target peptide accounts for at least 98% of the total detected area, indicating that truncated sequences, deletion products, and synthesis byproducts are present only in trace amounts. HPLC-UV is the standard characterization method for synthetic peptides in pharmaceutical and academic laboratories. 98% is the specification, which is a floor: the measured result for an individual lot is often higher. Where a Certificate of Analysis is issued for a lot, it reports the chromatographic result for that specific lot; CoA availability and level of detail vary by product and by lot.

Question 3

How should lyophilized peptides be stored?

Accepted Answer

Lyophilized peptide powder should be kept dry, sealed, and protected from light. Refrigeration at 2-8 °C is appropriate for short-term holding, while −20 °C or lower is used for extended storage of laboratory inventory. Moisture is the main variable to control, so a vial is best brought to ambient temperature before it is opened, preventing condensation from forming on the cold powder. Repeated freeze-thaw cycling should be avoided, since each cycle contributes to gradual degradation. Stability characteristics differ between sequences; consult the published literature for the specific peptide and any Certificate of Analysis issued for the lot.

AOD-9604 (5 mg)

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