Question 1

What is CJC-1295 No DAC (Modified GRF 1-29)?

Accepted Answer

CJC-1295 No DAC, commonly written Modified GRF (1-29), is a synthetic analog of the first twenty-nine amino acids of GHRH — the shortest fragment of that sequence retaining full receptor activity. Four amino acid substitutions increase resistance to enzymatic degradation while leaving the short duration of action intact, so the molecule reproduces a pulsatile rather than sustained signaling pattern in experimental models. It is frequently combined with a ghrelin receptor agonist in published study designs. Prime Science Supply supplies it as a Research Use Only material, not intended for human or veterinary use.

Question 2

What does purity of at least 98% by HPLC-UV mean?

Accepted Answer

High-performance liquid chromatography with ultraviolet detection separates the components of a sample and measures the area under each resulting peak. A result of at least 98% purity means the peak corresponding to the target peptide accounts for at least 98% of the total detected area, indicating that truncated sequences, deletion products, and synthesis byproducts are present only in trace amounts. HPLC-UV is the standard characterization method for synthetic peptides in pharmaceutical and academic laboratories. 98% is the specification, which is a floor: the measured result for an individual lot is often higher. Where a Certificate of Analysis is issued for a lot, it reports the chromatographic result for that specific lot; CoA availability and level of detail vary by product and by lot.

Question 3

How should lyophilized peptides be stored?

Accepted Answer

Lyophilized peptide powder should be kept dry, sealed, and protected from light. Refrigeration at 2-8 °C is appropriate for short-term holding, while −20 °C or lower is used for extended storage of laboratory inventory. Moisture is the main variable to control, so a vial is best brought to ambient temperature before it is opened, preventing condensation from forming on the cold powder. Repeated freeze-thaw cycling should be avoided, since each cycle contributes to gradual degradation. Stability characteristics differ between sequences; consult the published literature for the specific peptide and any Certificate of Analysis issued for the lot.

CJC-1295 No DAC (2 mg)

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