Question 1

What is Epithalon?

Accepted Answer

Epithalon, also written Epitalon, is a synthetic four-amino-acid peptide with the sequence Ala-Glu-Asp-Gly (AEDG). It was designed from epithalamin, a peptide preparation obtained from pineal tissue in Russian research programs, and it is one of the short synthetic peptides commonly grouped with the bioregulator class. Published work examines it in cultured cells, with attention to telomerase gene expression and chromatin-level regulation. Prime Science Supply supplies Epithalon as a Research Use Only material. It is not an approved drug and is not intended for human or veterinary use.

Question 2

Is Epithalon studied in relation to telomerase?

Accepted Answer

Yes. The published in vitro literature on Epithalon centers on telomerase, the ribonucleoprotein enzyme that extends the repetitive DNA sequence at chromosome ends. Studies in human somatic cell cultures have reported changes in telomerase expression following exposure to the tetrapeptide, and the mechanisms proposed in that literature involve interaction with promoter regions of the telomerase gene. These findings remain an area of active scientific discussion rather than settled consensus, and much of the primary work is confined to cell culture. Prime Science Supply makes no claim about outcomes in any organism.

Question 3

What does purity of at least 98% by HPLC-UV mean?

Accepted Answer

High-performance liquid chromatography with ultraviolet detection separates the components of a sample and measures the area under each resulting peak. A result of at least 98% purity means the peak corresponding to the target peptide accounts for at least 98% of the total detected area, indicating that truncated sequences, deletion products, and synthesis byproducts are present only in trace amounts. HPLC-UV is the standard characterization method for synthetic peptides in pharmaceutical and academic laboratories. 98% is the specification, which is a floor: the measured result for an individual lot is often higher. Where a Certificate of Analysis is issued for a lot, it reports the chromatographic result for that specific lot; CoA availability and level of detail vary by product and by lot.

Question 4

How should lyophilized peptides be stored?

Accepted Answer

Lyophilized peptide powder should be kept dry, sealed, and protected from light. Refrigeration at 2-8 °C is appropriate for short-term holding, while −20 °C or lower is used for extended storage of laboratory inventory. Moisture is the main variable to control, so a vial is best brought to ambient temperature before it is opened, preventing condensation from forming on the cold powder. Repeated freeze-thaw cycling should be avoided, since each cycle contributes to gradual degradation. Stability characteristics differ between sequences; consult the published literature for the specific peptide and any Certificate of Analysis issued for the lot.

Epithalon (50 mg)

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